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From years of using toxic aerosol products without any type of protective mask, Iz was diagnosed with kidney failure in 1996. In early 2000, in an interview for Style Wars revisited, he commented that he would give up all his past fame for full health. In August of 2003 he held a gallery showcasing his legal artwork in New York.
IZ also had his art cameoed in the game: Marc Ecko's Getting Up.
After struggling with kidney failure for many years, Iz The Wiz passed away on the 17th of June, 2009